Abacavir–Lamivudine versus Tenofovir–Emtricitabine for Initial HIV-1 Therapy
نویسندگان
چکیده
منابع مشابه
Nevirapine- Versus Lopinavir/Ritonavir-Based Initial Therapy for HIV-1 Infection among Women in Africa: A Randomized Trial
BACKGROUND Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based initial ART. METHODS AND FINDINGS In seven African countries (Botswana, Kenya, Malawi, South Africa, Uganda, Zambia, and Zimbabwe), 500 antiretroviral-naïve HIV-infecte...
متن کاملEarly versus deferred antiretroviral therapy for HIV.
To the Editor: Kitahata et al. (April 30 issue)1 addressed the question of whether persons who received antiretroviral therapy during their study lived longer if that treatment was initiated early rather than deferred. Through careful selection and censoring of patients in various subgroups, the authors attempted to eliminate a variety of sources of bias. However, in censoring patients who did ...
متن کاملOnce-daily maraviroc versus tenofovir/emtricitabine each combined with darunavir/ritonavir for initial HIV-1 treatment
OBJECTIVE The aim of this study was to evaluate the efficacy of maraviroc along with darunavir/ritonavir, all once daily, for the treatment of antiretroviral-naive HIV-1 infected individuals. DESIGN MODERN was a multicentre, double-blind, noninferiority, phase III study in HIV-1 infected, antiretroviral-naive adults with plasma HIV-1 RNA at least 1000 copies/ml and no evidence of reduced susc...
متن کاملLong versus Standard Initial Steroid Therapy for Children
Objectives: Two regimens of steroid treatment for the first episodes of idiopathic nephrotic syndrome in children were compared to address whether a longer initial course provides superior protection against relapse without increased adverse effects. The standard regimen consisted of prednisone 60 mg/m2 or 2 mg/kg per day for 4 weeks, followed by 40 mg/m2 or 1.5 mg/kg alternate-day prednisone f...
متن کاملComparison of sequential three-drug regimens as initial therapy for HIV-1 infection.
BACKGROUND The optimal sequencing of antiretroviral regimens for the treatment of infection with human immunodeficiency virus type 1 (HIV-1) is unknown. We compared several different antiretroviral treatment strategies. METHODS This multicenter, randomized, partially double-blind trial used a factorial design to compare pairs of sequential three-drug regimens, starting with a regimen includin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2009
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa0906768